Publications & Patents

Below is a list of publications from the CT Diagnostic Imaging Center at UW.

Refereed & Peer Reviewed Publications

Refereed & Peer Reviewed Publications

  1. Y. Li, J. W Garrett1, K. Li, Y. Wu, K. Johnson, S. Schafer, C. Strother and G.-H. Chen, Time-resolved C-arm cone beam CT angiography (TR-CBCTA) imaging from a single short-scan C-arm cone beam CT acquisition with intra-arterial contrast injection, Physics in Medicine & Biology, Vol. 63(7):075001, 2018 [DOI]
  2. Y. Li, M. Speidel, C. Francois, and G.-H. Chen, Radiation dose reduction in CT Myocardial Perfusion Imaging using SMART-RECON, IEEE TMI, Vol. 36(12):2557-2568(2017)
  3. B.J. Walker, J. Radtke, G.-H. Chen, K.W. Eliceiri, T.R. Mackie, A beam optics study of a modular multi-source X-ray tube for novel computed tomography applications, Nuclear Inst. and Methods in Physics Research, A, 868(2017)1-9
  4. Y. Ge, Xu Ji, R. Zhang, K. Li, G.-H. Chen, K-edge energy-based calibration method for photon counting detectors, Phys. Med. Biol. 63 015022(2018)
  5. J. P. Cruz-Bastida, D. Gomez-Cardona, J. Garrett, T. Szczykutowicz, G.-H. Chen, K. Li, Modified ideal observer model (MIOM) for high-contrast and high-spatial resolution CT imaging tasks, Medical Physics Vol. 44, pp 4496-4505, 2017 [DOI]
  6. P. Yang, K. Niu, Y. Wu, T. Struffert, A. Doerfler, P. Holter, B. Aagaard-Kienitz, C. Strother, G.-H. Chen, Evaluation of Collaterals and Clot Burden Using Time-Resolved C-Arm Conebeam CT Angiography in the Angiography Suite: A Feasibility Study, AJNR Am J Neuroradiol 2017;38(4):747-752
  7. X. Ji, Y. Ge, R. Zhang, K. Li, G.-H. Chen, Studies of signal estimation bias in grating-based x-ray multicontrast imaging, Med. Phys., Vol.44 (6), DOI: 10.1002/mp.12235
  8. Y. Chen, A. Budde, K. Li, Y. Li, J. Hsieh, G.-H. Chen, A platform-independent method to reduce CT truncation artifacts using discriminative dictionary representations, Medical Physics Vol. 44, pp. 121–131, 2017 [DOI]
  9. H. Kramer, P. J. Pickhardt, M. A. Kliewer, D. Hernando, G.-H. Chen, J. A. Zagzebski, S. B. Reeder, Accuracy of Liver Fat Quantification With Advanced CT, MRI, and Ultrasound Techniques: Prospective Comparison With MR Spectroscopy, American Journal of Roentgenology:1-9, 2016[DOI]
  10. B. D. Pooler, M. G. Lubner, D. H. Kim, O. T. Chen, K. Li, G.-H. Chen, P. J. Pickhardt, Prospective Evaluation of Reduced Dose Computed Tomography for the Detection of Low-Contrast Liver Lesions: Direct Comparison with Concurrent Standard Dose Imaging, European Radiology, 2016 [DOI]
  11. D. Gomez-Cardona, J. P. Cruz-Bastida, K. Li, A. Budde, J. Hsieh and G.-H. Chen, Impact of bowtie filter and object position on the two-dimensional noise power spectrum of a clinical MDCT system, Medical Physics, Vol. 43, pp. 4495-4506, 2016 [DOI]
  12. Y. Ge, R. Zhang, K. Li, and G.-H. Chen, Improving radiation dose efficiency of X-ray differential phase contrast imaging using an energy-resolving grating interferometer and a novel rank constraint, Optics Express, Vol. 24 (12), pp. 12955-12968, 2016 [DOI]
  13. K. Niu, P. Yang, Y. Wu, T. Struffert, A. Doerfler, S. Schafer, K. Royalty, C. Strotherand, and G.-H. Chen, C-Arm Conebeam CT Perfusion Imaging in the Angiographic Suite: A Comparison with Multidetector CT Perfusion Imaging, American Journal of Neuroradiology, (Epub ahead of print), 2016 [DOI]
  14. J. P. Cruz-Bastida, D. Gomez-Cardona, K. Li, H. Sun, J. Hsieh, T. P. Szczykutowicz, and G.-H. Chen, Hi-Res scan mode in clinical MDCT systems: Experimental assessment of spatial resolution performance, Medical Physics, Vol. 43, pp. 2399, 2016 [DOI]
  15. D. Gomez-Cardona, K. Li, J. Hsieh, M. G. Lubner, P. J. Pickhardt and G.-H. Chen, Can conclusions drawn from phantom-based image noise assessments be generalized to in vivo studies for the nonlinear model-based iterative reconstruction method?, Medical Physics, Vol. 43, pp. 687, 2016[DOI]
  16. P. Bannas, Y. Li, U. Motosugi, K. Li, M. G. Lubne, G.-H. Chen, P. J. Pickhardt, Prior Image Constrained Compressed Sensing Metal Artifact Reduction (PICCS-MAR): 2D and 3D Image Quality Improvement with Hip Prostheses at CT Colonograph, European Radiology, 2015 [DOI]
  17. P. Yang, K. Niu, Y. Wu, T. Struffert, A. Dorfler, S. Schafer, K. Royalty, C. Strother, G.-H. Chen, Time-Resolved C-Arm Computed Tomographic Angiography Derived From Computed Tomographic Perfusion Acquisition: New Capability for One-Stop-Shop Acute Ischemic Stroke Treatment in the Angiosuite, Stroke, Vol 46 2015 [DOI]
  18. X. An, M. S. Brittelle, P. Theriault-Lauzier, J. R. Gord, S. Roy, G.-H. Chen, and S. T. Sanders, Demonstration of temperature imaging by H2O absorption spectroscopy using compressed sensing tomography, Applied Optics, Vol. 54, pp.9190 2015 [DOI]
  19. G.-H. Chen, Y. Li, Synchronized multiartifact reduction with tomographic reconstruction (SMART-RECON): A statistical model based iterative image reconstruction method to eliminate limited-view artifacts and to mitigate the temporal-average artifacts in time-resolved CT, Medical Physics, Vol 42, pp. 4698 2015 [DOI]
  20. D. Gomez-Cardona, S. K. Nagle, K. Li, T. E. Robinson, G.-H. Chen, Influence of radiation dose and reconstruction algorithm in MDCT assessment of airway wall thickness: A phantom study, Medical Physics, Vol. 42, pp. 5919-5927, 2015 [DOI]
  21. J. Garrett, Y. Ge, K. Li, G.-H. Chen, Correction of data truncation artifacts in differential phase contrast (DPC) tomosynthesis imaging, Physics in Medicine and Biology, Vol. 60, pp.7713 2015[DOI]
  22. W. Zhao, K. Niu, S. Schafer and K. Royalty, An indirect transmission measurement-based spectrum estimation method for computed tomography, Phys. Bio. Med., Vol. 60, pp. 339, 2015 [DOI]
  23. K. Li, D. Gomez-Cardona, J. Hsieh, M. G. Lubner, P. J. Pickhardt and G.-H. Chen, Statistical model based iterative reconstruction in clinical CT systems. Part III. Task-based kV/mAs optimization for radiation dose reduction, Medical Physics, Vol. 42, pp. 5209 2015 [DOI]
  24. Lubner M.G., Pooler B.D., Kitchin D.R., Tang J., Li K., Kim D.H., Del Rio A.M., Chen G.-H., Pickhardt P.J., Sub-milliSievert (sub-mSv) CT colonography: a prospective comparison of image quality and polyp conspicuity at reduced-dose versus standard-dose imaging, European Radiology, Vol. 25, pp. 2089-2102 2015 [DOI]
  25. Zhao, W., Brunner, S., Niu, K., Schafer, S., Royalty, K., Chen, G.-H., Patient-specific scatter correction for flat-panel detector-based cone-beam CT imaging, Physics in Medicine and Biology, 2015, Vol. 60, pp. 1339 [DOI]
  26. J. Garrett, Y. Ge, K. Li and G.-H. Chen, Anatomical background noise power spectrum in differential phase contrast and dark field contrast mammograms, Medical Physics, 2014, Vol. 41, pp. 120701 [DOI]
  27. Pooler, B.D., Lubner, M.G., Kim, D.H., Ryckman, E.M., Sivalingam, S., Tang, J., Nakada, S.Y., Chen, G.-H., Pickhardt, P.J., Prospective evaluation of prior image constrained compressed sensing (PICCS) algorithm in abdominal CT: a comparison of reduced dose with standard dose imaging, Abdominal Imaging, 2014 [Pubmed]
  28. Prospective Trial of the Detection of Urolithiasis on Ultralow Dose (Sub mSv) Noncontrast Computerized Tomography: Direct Comparison against Routine Low Dose Reference Standard., Urology, 2014 [Pubmed]
  29. Li, K., Garrett, J., Ge, Y. & Chen, G.-H., Statistical model based iterative reconstruction (MBIR) in clinical CT systems. Part II. Experimental assessment of spatial resolution performance, Medical Physics, 2014, Vol. 41 (7), pp. 071911 [DOI]
  30. Tao, Y., Chen,G.-H., Hacker, T., Raval, A., Van Lysel, M. and Speidel, M., Low dose dynamic CT myocardial perfusion imaging using a statistical iterative reconstruction method, Medical Physics, 2014, Vol. 41 (7), pp. 071914 [DOI]
  31. Ge, Y., Li, K., Garrett, J., Chen, G.-H., Grating based x-ray differential phase contrast imaging without mechanical phase stepping, Optics Express, 2014, Vol. 22 (12), pp. 14246-14252 [DOI]
  32. Li, K., Tang, J. & Chen, G.-H. Statistical model based iterative reconstruction (MBIR) in clinical CT systems: Experimental assessment of noise performance, Medical Physics, 2014, Vol. 41(4), pp. 041906 [DOI] [URL]
  33. Li, K., Ge, Y., Garrett, J., Bevins, N., Zambelli, J. & Chen, G.-H. Grating-based phase contrast tomosynthesis imaging: Proof-of-concept experimental studies, Medical Physics, 2014, Vol. 41(1), pp. 011903 [DOI] [URL]
  34. Li, K., Garrett, J., & Chen, G.-H. Correlation between human observer performance and model observer performance in differential phase contrast CT, Medical Physics, 2013, Vol. 40(11), pp. 111905 [DOI] [URL]
  35. Li, K., Zambelli, J., Bevins, N., Ge, Y., & Chen, G.-H. Spatial resolution characterization of differential phase contrast CT systems via modulation transfer function (MTF) measurements, Physics in Medicine and Biology, 2013, Vol. 58(12), pp. 4119 [DOI] [URL]
  36. Li, K., Bevins, N., Zambelli, J., & Chen, G.-H. Fundamental relationship between the noise properties of grating-based differential phase contrast CT and absorption CT: Theoretical framework using a cascaded system model and experimental validation, Medical Physics, 2013, Vol. 40(2), pp. 021908[DOI] [URL]
  37. Theriault-Lauzier, P. & Chen, G.-H. Characterization of statistical prior image constrained compressed sensing. II. Application to dose reduction, Medical Physics, 2013, Vol. 40(2), pp. 021902 [DOI] [URL]
  38. McCollough, C. H., Chen, G.-H., Kalender, W., Leng, S., Samei, E., Taguchi, K., Wang, G., Yu, L. & Pettigrew, R. I. Achieving routine submillisievert CT scanning: report from the summit on management of radiation dose in CT Radiology, 2012, Vol. 264(2), pp. 567-580 [URL]
  39. Theriault-Lauzier, P. & Chen, G.-H. Characterization of statistical prior image constrained compressed sensing. I. Applications to time-resolved contrast-enhanced CT Medical Physics, AAPM, 2012, Vol. 39(10), pp. 5930-5948 [DOI] [URL]
  40. Pickhardt, P., Lubner, M., Kin, D., Tang, J., Ruma, J., Munoz del Rio, A. & Chen, G.-H. Abdominal CT with model-based iterative reconstruction (MBIR): initial results of a prospective trial comparing ultralow-dose with standard-dose imaging American Journal of Roentgenology, 2012, Vol. 199 [URL]
  41. Artz, N., Hines, C., Brunner, S., Agni, R, Kuhn, J.-P., Roldan-Alzate, A., Chen, G.-H. & Reeder, S. Quantification of hepatic steatosis with dual-energy computed tomography Investigative Radiology, 2012, Vol. 47(10), pp. 603–610 [URL]
  42. Theriault-Lauzier, P., Qi, Z., Zambelli, J., Bevins, N. & Chen, G.-H. Interior tomography in x-ray differential phase contrast CT imaging Physics in Medicine and Biology, 2012, Vol. 57(9), pp. N117 [DOI] [URL]
  43. Theriault-Lauzier, P., Tang, J. & Chen, G.-H. Time-resolved cardiac interventional cone-beam CT reconstruction from fully truncated projections using the prior image constrained compressed sensing (PICCS) algorithm Physics in Medicine and Biology, 2012, Vol. 57(9), pp. 2461 [DOI] [URL]
  44. Theriault-Lauzier, P., Tang, J., Speidel, M.A. & Chen, G.-H. Noise spatial nonuniformity and the impact of statistical image reconstruction in CT myocardial perfusion imaging Medical Physics, AAPM, 2012, Vol. 39(7), pp. 4079-4092 [DOI] [URL]
  45. Bevins, N., Zambelli, J., Li, K., Qi, Z. & Chen, G.-H. Multi-contrast x-ray computed tomography imaging using Talbot-Lau interferometry without phase stepping Med. Phys., 2012, Vol. 39(1), pp. 424-428 [DOI]
  46. Theriault-Lauzier, P., Tang, J. & Chen, G. Prior image constrained compressed sensing: Implementation and performance evaluation Med. Phys., 2012, Vol. 39(1), pp. 66 [DOI]
  47. Chen, G.-H., Theriault-Lauzier, P., Tang, J., Nett, B., Leng, S., Zambelli, J., Qi, Z., Bevins, N., Raval, A., Reeder, S. & Rowley, H. Time-Resolved Interventional Cardiac C-arm Cone-Beam CT: An Application of the PICCS Algorithm Medical Imaging, IEEE Transactions on, 2012, Vol. 31(4), pp. 907 -923 [DOI]
  48. Chen, G.-H., Zambelli, J., Li, K., Bevins, N. & Qi, Z. Scaling law for noise variance and spatial resolution in differential phase contrast computed tomography Med. Phys., 2011, Vol. 38(2), pp. 584-588 [DOI] [URL]
  49. Brunner, S., Nett, B.E., Tolakanahalli, R. & Chen, G.-H. Prior image constrained scatter correction in cone-beam computed tomography image-guided radiation therapy Physics in Medicine and Biology, 2011, Vol. 56(4), pp. 1015 [DOI] [URL]
  50. Lubner, M., Pickhardt, P., Tang, J. & Chen, G. Reduced image noise at low-dose multidetector CT of the abdomen with prior image constrained compressed sensing algorithm Radiology, Radiological Society of North America, 2011, Vol. 260(1), pp. 248-256 [DOI]
  51. Qi, Z. & Chen, G. Extraction of tumor motion trajectories using PICCS-4DCBCT: A validation studyMed. Phys., 2011, Vol. 38, pp. 5530 [DOI]
  52. Qi, Z. & Chen, G. Performance studies of four-dimensional cone beam computed tomography Phys. Med. Biol., IOP Publishing, 2011, Vol. 56, pp. 6709 [DOI]
  53. Chen, G.-H., Zambelli, J., Bevins, N., Qi, Z. & Li, K. X-ray phase sensitive imaging methods: basic physical principles and potential medical applications Curr. Med. Imaging Rev., 2010, Vol. 6(2), pp. 90-99 [URL]
  54. Chen, G.-H., Tang, J., Nett, B., Qi, Z., Leng, S. & Szczykutowicz, T. Prior Image Constrained Compressed Sensing (PICCS) and Applications in X-ray Computed Tomography Curr. Med. Imaging Rev., 2010, Vol. 6(2), pp. 119-134 [URL]
  55. Chen, G.-H., Bevins, N., Zambelli, J. & Qi, Z. Small-angle scattering computed tomography (SAS-CT) using a Talbot-Lau interferometer and a rotating anode x-ray tube: theory and experimentsOpt. Express, 2010, Vol. 18(12), pp. 12960-12970 [DOI] [URL]
  56. Nett, B.E., Brauweiler, R., Kalender, W., Rowley, H. & Chen, G.-H. Perfusion measurements by micro-CT using prior image constrained compressed sensing (PICCS): initial phantom results Phys. Med. Biol., 2010, Vol. 55(8), pp. 2333 [DOI] [URL]
  57. Qi, Z., Zambelli, J., Bevins, N. & Chen, G.-H. Quantitative imaging of electron density and effective atomic number using phase contrast CT Phys. Med. Biol., 2010, Vol. 55, pp. 2669–-2677 [DOI][URL]
  58. Szczykutowicz, T. & Chen, G. Dual energy CT using slow kVp switching acquisition and prior image constrained compressed sensing Phys. Med. Biol., IOP Publishing, 2010, Vol. 55, pp. 6411 [DOI]
  59. Tang, J., Hsieh, J. & Chen, G. Temporal resolution improvement in cardiac CT using PICCS (TRI-PICCS): Performance studies Med. Phys., 2010, Vol. 37, pp. 4377 [DOI]
  60. Zambelli, J., Bevins, N., Qi, Z. & Chen, G.-H. Radiation dose efficiency comparison between differential phase contrast CT and conventional absorption CT Med. Phys., 2010, Vol. 37, pp. 2473-2479 [DOI] [URL]
  61. Chen, G.-H., Tang, J. & Hsieh, J. Temporal resolution improvement using PICCS in MDCT cardiac imaging Med. Phys., 2009, Vol. 36(6), pp. 2130-2135 [DOI] [URL]
  62. Supanich, M., Tao, Y., Nett, B., Pulfer, K., Hsieh, J., Turski, P., Mistretta, C., Rowley, H. & Chen, G.-H. Radiation dose reduction in time-resolved CT angiography using highly constrained back projection reconstruction. Phys. Med. Biol., 2009, Vol. 54(14), pp. 4575-4593 [DOI] [URL]
  63. Tang, J., Nett, B.E. & Chen, G.-H. Performance comparison between total variation (TV)-based compressed sensing and statistical iterative reconstruction algorithms. Phys. Med. Biol., 2009, Vol. 54(19), pp. 5781-5804 [DOI] [URL]
  64. Chen, G.-H. & Qi, Z. Image reconstruction for fan-beam differential phase contrast computed tomography Phys. Med. Biol., 2008, Vol. 53(4), pp. 1015-1025 [DOI] [URL]
  65. Chen, G.-H., Tang, J. & Leng, S. Prior image constrained compressed sensing (PICCS): A method to accurately reconstruct dynamic CT images from highly undersampled projection data sets Med. Phys., AAPM, 2008, Vol. 35(2), pp. 660-663 [DOI] [URL]
  66. Leng, S., Tang, J., Zambelli, J., Nett, B., Tolakanahalli, R. & Chen, G.-H. High temporal resolution and streak-free four-dimensional cone-beam computed tomography Phys. Med. Biol., Department of Medical Physics, University of Wisconsin-Madison, WI 53792-1590, USA., 2008, Vol. 53(20), pp. 5653-5673 [DOI] [URL]
  67. Leng, S., Zambelli, J., Tolakanahalli, R., Nett, B., Munro, P., Star-Lack, J., Paliwal, B. & Chen, G.-H. Streaking artifacts reduction in four-dimensional cone-beam computed tomography Med. Phys., AAPM, 2008, Vol. 35(10), pp. 4649-4659 [DOI] [URL]
  68. Nett, B., Leng, S., Zambelli, J., Reeder, S., Speidel, M. & Chen, G. Temporally Targeted Imaging Method Applied to ECG-Gated Computed Tomography Preliminary Phantom and In Vivo ExperienceAcad. Radiol., 2008, Vol. 15(1), pp. 93-106 [DOI] [URL]
  69. Qi, Z. & Chen, G.-H. Direct Fan-Beam Reconstruction Algorithm via Filtered Backprojection for Differential Phase-Contrast Computed Tomography X-Ray Opt. Instrum., 2008, Vol. 2008, pp. 835172 [DOI] [URL]
  70. Chen, G.-H., Zhuang, T.-L., Leng, S. & Nett, B.E. Cone-beam filtered backprojection image reconstruction using a factorized weighting function Opt. Eng., 2007, Vol. 46(8), pp. 087006 [DOI][URL]
  71. Leng, S., Zhuang, T., Nett, B. & Chen, G. Helical cone-beam computed tomography image reconstruction algorithm for a tilted gantry with N-PI data acquisition Opt. Eng., 2007, Vol. 46, pp. 015004 [DOI] [URL]
  72. Nett, B., Zhuang, T., Leng, S. & Chen, G. Arc based cone-beam reconstruction algorithm using an equal weighting scheme J. X-Ray Sci. Technol., IOS Press, 2007, Vol. 15(1), pp. 19-48 [URL]
  73. Qi, Z. & Chen, G.-H. A local region of interest image reconstruction via filtered backprojection for fan-beam differential phase-contrast computed tomography Phys. Med. Biol., 2007, Vol. 52, pp. N417–N423 [DOI] [URL]
  74. Chen, G.-H., Tokalkanahalli, R., Zhuang, T., Nett, B.E. & Hsieh, J. Development and evaluation of an exact fan-beam reconstruction algorithm using an equal weighting scheme via locally compensated filtered backprojection (LCFBP). Med. Phys., 2006, Vol. 33(2), pp. 475-481 [DOI] [URL]
  75. Zhuang, T. & Chen, G. New families of exact fan-and cone-beam image reconstruction formulaeInverse Probl., Institute of Physics Publishing, 2006, Vol. 22, pp. 991-1006 [DOI] [URL]
  76. Zhuang, T., Nett, B.E., Leng, S. & Chen, G.-H. A shift-invariant filtered backprojection (FBP) cone-beam reconstruction algorithm for the source trajectory of two concentric circles using an equal weighting scheme. Phys. Med. Biol., 2006, Vol. 51(12), pp. 3189-3210 [DOI] [URL]
  77. Chen, G.-H. & Leng, S. A new data consistency condition for fan-beam projection data Med. Phys., AAPM, 2005, Vol. 32(4), pp. 961-967 [DOI] [URL]
  78. Chen, G.-H., Leng, S. & Mistretta, C.A. A novel extension of the parallel-beam projection-slice theorem to divergent fan-beam and cone-beam projections Med. Phys., AAPM, 2005, Vol. 32(3), pp. 654-665 [DOI] [URL]
  79. Leng, S., Zhuang, T., Nett, B.E. & Chen, G.-H. Exact fan-beam image reconstruction algorithm for truncated projection data acquired from an asymmetric half-size detector. Phys. Med. Biol., 2005, Vol. 50(8), pp. 1805-1820 [DOI] [URL]
  80. Zhuang, T., Leng, S., Nett, B.E. & Chen, G.-H. Fan-beam and cone-beam image reconstruction via filtering the backprojection image of differentiated projection data. Phys. Med. Biol., 2004, Vol. 49(24), pp. 5489-5503 [DOI] [URL]
  81. Chen, G.-H. A new framework of image reconstruction from fan beam projections Med. Phys., AAPM, 2003, Vol. 30(6), pp. 1151-1161 [DOI] [URL]
  82. Chen, G.-H. An alternative derivation of Katsevich’s cone-beam reconstruction formula Med. Phys., AAPM, 2003, Vol. 30(12), pp. 3217-3226 [DOI] [URL]

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